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Akishige Hokugo, DDS, PhD
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Postdoctoral Researcher:
Member:
- International Association for Dental Research
- International Association of Oral and Maxillofacial Surgeons
- Japanese Society for Biomaterials
- Japanese Society of Oral and Maxillofacial Surgeons
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Contact Info:
The Weintraub Center for Reconstructive Biotechnology
UCLA School of Dentistry
Box 951668, CHS B3-087
Los Angeles, CA 90095-1668
Email: akishige@ucla.edu
Personal Info:
CURRICULUM VITAE (PDF)
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Educational and Professional Background
D.D.S., 1999, Osaka Dental University, Osaka, Japan
Ph.D., 2003, Graduate School of Dentistry, Osaka Dental University, Osaka, Japan
Dr. Akishige Hokugo received his dental degree (D.D.S.) in 1999 from Osaka Dental University in Japan. He then entered the Graduate School of Dentistry in the First Department of Oral and Maxillofacial Surgery at the same university, where he received training in oral and maxillofacial surgery and research. He received his Ph.D. in 2003.
Dr. Hokugo was an oral surgeon in the Department of Oral and Maxillofacial Surgery at Osaka Dental University Hospital in Japan from 1999 to 2004. He then worked as a COE researcher (postdoctoral research fellow) in the Department of Biomaterials at the Institute for Frontier Medical Sciences of Kyoto University under the supervision of Prof. Yasuhiko Tabata from 2004 to 2006.
Dr. Hokugo was a postdoctoral research fellow of the Japan Society for the Promotion of Science (JSPS) from 2006 to 2008. He has also been a part-time lecturer in the First Department of Oral and Maxillofacial Surgery at Osaka Dental University since 2003.
Dr. Hokugo is now a Postdoctoral Scholar under Dr. Ichiro Nishimura in the Weintraub Center for Reconstructive Biotechnology at the UCLA School of Dentistry.
Research/Creative Activities
In Japan, Dr. Hokugo researched biodegradable polymers and hydrogels and their medical and dental applications. He also focused on bone and gingival regeneration based on tissue engineering technologies and drug delivery systems. He was awarded the Scientific Award from the Japanese Society of Oral and Maxillofacial Surgeons in 2003 and a Poster Award at the 25th Annual Meeting of the Japanese Academy of Clinical Periodontology in2007. He published four Japanese, one US, one Australian and one European patent applications as an inventor.
At UCLA, Dr. Hokugo’s research focuses on bisphosphonate-related osteonecrosis of the jaw (BRONJ) from the perspectives of osteoimmunology and bone metabolism. He also focuses on wound healing of gingiva and influence of vitamin D insufficiency for alveolar bone healing.
.Recent Publications:
- Hokugo A, Kubo Y, Takahashi Y, Fukuda A, Horiuchi K, Mushimoto K, Morita S, Tabata Y. Prefabrication of vascularized bone graft using guided bone regeneration. Tissue Eng. 10(7-8): 978-986, 2004.
- Hokugo A, Mushimoto K, Morita S, Tabata Y. Prefabricated vascularized bone graft using autologous tissue, biomaterials, and growth factors: A New Technique for Bone Reconstruction. Key Eng. Mater.288-289:51-54, 2005.
- Hokugo A, Ozeki M, Kawakami O, Sugimoto K, Mushimoto K, Morita S, Tabata Y. Augmented bone regeneration activity of platelet-rich plasma by biodegradable gelatin hydrogel. Tissue Eng. 11(7-8):1224-1233, 2005.
- Yamamoto M, Takahashi Y, Hokugo A, Tabata Y. Enhanced osteoinduction by biodegradable gelatin-b-tricalcium phosphate sponge capable for bone morphogenetic protein release. J Hard Tissue Biol. 14(2):286-287, 2005.
- Hokugo A, Sawada Y, Mushimoto K, Morita S, Tabata Y. Cranial bone regeneration by controlled release of platelet growth factors from biodegradable hydrogel. J Hard Tissue Biol. 14(2):288-290, 2005.
- Hokugo A, Takamoto T, Tabata Y. Preparation of hybrid scaffold from fibrin and biodegradable polymer fiber. Biomaterials 27(1):61-67, 2006.
- Hokugo A, Tabata Y. Recent advances in tissue engineering for regeneration of oral tissues. Inflammation and Regeneration 26(2): 82-91, 2006. (Review)
- Kamada A, Ikeo T, Tamura I, Goda S, Kawamoto A, Okazaki J, Komasa Y, Hokugo A, Morita S. Statin Promotes Mineralization Potential in MC3T3-E1 Nonmineralizing Subclone. J Oral Tissue Eng. 3(3):169-174, 2006.
- Kamada A, Ikeo T, Tamura I, Goda S, Yoshikawa Y., Domae E., Kawamoto A, Okazaki J, Komasa Y, Hayashi H., Hokugo A, Iseki T., Morita S.: Statin Enhances Osteoblast Differentiation by Suppression of Runx2 Overexpression. J Oral Tissue Eng. 4(1):9-16, 2006.
- Hokugo A, Sugimoto K, Fukuda A, Sawada Y, Mushimoto K, Morita S, Tabata Y. Preparation of prefabricated vascularized bone graft with neoangiogenesis by combination of autologous tissue and biodegradable materials. Int J Oral Maxillofac Surg. 35(11):1034-40, 2006.
- Takaba K, Jiang C, Nemoto S, Saji Y, Ikeda T, Urayama S, Azuma T, Hokugo A, Tsutsumi S, Tabata Y, Komeda M.: A combination of omental flap and growth factor therapy induces arteriogenesis and increases myocardial perfusion in chronic myocardial ischemia: Evolving concept of biologic coronary artery bypass grafting. J Thorac Cardiov Surg. 132(4):891-99, 2006.
- Ishida K, Kuroda R, Miwa M, Tabata Y, Hokugo A, Kawamoto T, Sasaki K, Doita M, Kurosaka M. The regenerative effects of platelet-rich plasma on meniscal cells in vitro and its in vivo application with biodegradable gelatin hydrogel. Tissue Eng. 13(5):1103-12, 2007.
- Hokugo A, Sawada Y, Hokugo R, Iwamura H, Kobuchi M, Kambara T, Morita S, Tabata Y. Controlled release of platelet growth factors enhances bone regeneration at rabbit calvaria. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 104(1):44-8, 2007.
- Wang CJ, Iida K, Egusa H, Hokugo A, Jewett A, Nishimura I. Trabecular bone deterioration in col9a1+/- mice associated with enlarged osteoclasts adhered to collagen IX-deficient bone. J Bone Miner Res. 23(6):837-49, 2008.
- Kimura Y, Hokugo A, Takamoto T, Tabata Y, Kurosawa H. Regeneration of anterior cruciate ligament by biodegradable scaffold combined with local controlled release of basic fibroblast growth factor and collagen wrapping. Tissue Eng Part C Methods. 14(1):47-57, 2008.
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