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    Takahiro Ogawa , DDS, PhD

Associate Professor:

Executive Member:

Note: Great news for young investigators! See the details of a new IADR award “Pre-Prosthetic Regenerative Science Award” established by Dr. Ogawa.

Dr. Ogawa’s Implant activation technology has been featured in a UCLA Invention magazine.

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Contact Info:

The Weintraub Center for Reconstructive Biotechnology
UCLA School of Dentistry
Box 951668, CHS B3-087
Los Angeles, CA 90095-1668

Email:

togawa@dentistry.ucla.edu

Dr. Takahiro Ogawa is the Director of the Laboratory of Bone and Implant Sciences (LBIS) in the Weintraub Center. He received DDS and PhD from Kyushu University in Japan and is currently an Associate Professor for the Division of Advanced Prosthodontics at UCLA. He is also involved in maxillofacial prosthetics within the UCLA School of Dentistry, and serves as Secretary and Treasurer for the IADR Prosthodontics Research Group.  He holds over 10 patents related to implants and biomaterials, has over 190 article and abstract publications, and has presented his work at over 120 leading national and international scientific meetings. Dr. Ogawa’s research on bone regeneration and biomaterial sciences has been recognized both nationally and worldwide; and he has been honored and awarded by numerous academies and institutions, including the National Institutes of Health.

Quote:

“Joy of Eating—Joy of Motion for Everybody: The mission of our Laboratory for Bone and Implant Sciences (LBIS) is to reestablish the joy of eating and the joy of motion for those suffering from diseased or injured bone and missing teeth. The laboratory’s goal is to biologically and functionally restore damaged or defective bone and teeth by delivering biomaterial-driven bone-regenerative therapies. Special emphasis is placed on the research and development of metallic implants in bone as a reconstructive anchor; with the aim to develop more versatile and secure dental implants. The LBIS’ convergence of spirit, talent, and knowledge, together with the state-of-the-art facilities and innovative colleagues within the Weintraub Center, will provide an optimal environment to reach our goals.”

Patented Technologies :
  1. Physicochemical modification of bone and dental implants
  2. Controlled nanosphere structuring for metal, nonmetal and semiconductor materials
  3. Detoxified and osteoconductive bone cement
  4. Detoxified dental resin
  5. A novel osteogenic enhancer and its application

Recent Publications:

  • Tsukimura N, Kojima N, Kubo K, Att W, Takeuchi K, Kameyama Y, Maeda H,  Ogawa T. The effect of superficial chemistry of titanium on osteoblastic function. J Biomed Mater Res A, 84A:108-116, 2008
  • Kojima N, Ozawa S, Tanaka T, Ogawa T. DNA microarray analysis of gene expression in bone healing around titanium implant. Clin Oral Imp Res, 19;173-181, 2008
  • Yamada M, Kojima N, Paranjpe A, Att W, Aita H, Jewett A, Ogawa T. N-acetyl cysteine (NAC)-assisted detoxification of poly-methyl methacrylate (PMMA) resin. J Dent Res 87:372-377, 2008
  • Aita H, Oh W, Kubo K, Tsukimura N, Maeda H, Ogawa T. Bone cement-philic titanium surface. J Mater Sci 43:1552-1558, 2008
  • Ogawa T, Saruwatari L, Takeuchi K, Aita H, Ohno N. Ti nano-nodular structuring for bone integration and regeneration. J Dent Res, 87:751-756, 2008
  • Hasegawa H, Ozawa S, Hashimoto K, Ogawa T. Type II diabetes (non-insulin-dependent, adult-onset diabetes mellitus) impairs implant osseointegration capacity. Int J Oral Maxillofac Implant, 23:237-246, 2008
  • Aita H, Ogawa T. Nanotechnology for implant dentistry. J Biomaterials, 26:234-246, 2008
  • Kubo K, Att W, Yamada M, Tsukimura N, Maeda H, Ogawa T. Microtopography of titanium suppresses osteoblastic differentiation but enhances chondroblastic differentiation of rat femoral periosteum-derived cells. J Biomed Mater Res A, 87A: 380-391, 2008
  • Kojima N, Yamada M, Paranjpe A, Tsukimura N, Kubo K, Jewett A,  Ogawa T.  Restored viability and function of dental pulp cells on poly-methylmethacrylate (PMMA)-based dental resin supplemented with N-acetyl cysteine (NAC). Dental Materials, 24:1686-1693, 2008
  • Att W, Yamada M, Kojima N, Ogawa T. N-acetyl cysteine (NAC) prevents suppression of oral fibroblast function on poly-methyl methacrylate (PMMA) resin. Acta Biomaterialia, 5:391-398, 2009
  • Att W, Yamada M, Ogawa T. Titanium surface characteristics affect behavior and function of oral fibroblasts. Int J Oral Maxillofac Implants, in press
  • Aita H, Tsukimura N, Yamada M, Hori N, Kubo K, Sato N, Maeda H, Kimoto K,  Ogawa T. N-acetyl cysteine (NAC) prevents polymethyl methacrylate (PMMA) bone cement extract-induced cell death and functional suppression of rat primary osteoblasts. J Biomed Mater Res A, epublished 10.1002/jbm.a.32336
  • Aita H, Hori N, Takeuchi M, Suzuki T, Yamada M, M, Anpo, Ogawa T. The effect of ultraviolet functionalization of titanium on integration with bone. Biomaterials, 30:1015-1025, 2009
  • Shim J, Nakamura H, Ogawa T, Gupta V. An Understanding of the Mechanism that Promotes Adhesion Between Roughened Titanium Implants and Mineralized Tissue. J Biomech Eng, 131:054503
  • Att W, Kubo K, Yamada M, Maeda H, Ogawa T. Biomechanical quality of jaw periosteum-derived mineralized culture on different titanium topography. Int J Oral Maxillofac Implants, in press
  • Yamada M, Kojima N, Att W, Hori N, Suzuki T, Ogawa T. N-Acetyl cysteine restores viability and function of rat odontoblast-like cells impaired by polymethylmethacrylate dental resin extract. Redox Rep, 14:13-22, 2009
  • Att W, Takeuchi M, Suzuki T, Kubo K, Anpo M, Ogawa T. Enhanced osteoblast function on ultraviolet light-treated zirconia. Biomaterials, 30: 1273–1280, 2009
  • Yamada M, Ueno T, Hori N, Ogawa T. Cell biological consideration of the mechanism underlying polymethyl methacrylate dental resin cytotoxicity in oral mucosal cells. J Jpn Prosthodont Soc, in press
  • Ueno T, Yamada M, Hori N, Suzuki T, Ogawa T. UV photo-activation of titanium enhances osseointegration in a rat model.  Int J Oral Maxillofac Implants, in press
  • Kimoto K, Kimoto K, Suzuki T, Ohno M, Ogawa T. Nano-structure-mediated functionalization of titanium: Effects of nanonodular structuring on protein adsorption and cell attachment capacities. Jpn J Oral Implant, in press
  • Tsukimura N, Yamada M, Aita H, Hori N, Yoshino F, Lee MC, Kimoto K, Jewett A, Ogawa T. N-acetyl cysteine (NAC)-mediated detoxification and functionalization of poly(methyl methacrylate) bone cement. Biomaterials, epublished, doi:10.1016/j.biomaterials.2009.02.043   
  • Hori N, Att W, Ueno T, Sato N, Yamada M, Saruwatari L, Suzuki T, Ogawa T. Age-dependent degradation of protein adsorption capacity of Ti. J Dent Res, in press
  • Aita H, Att W, Ueno T, Yamada M, Hori N, Iwasa F, Tsukimura N, Ogawa T. Ultraviolet (UV) light-mediated photofunctionalization of titanium to promote human mesenchymal stem cell migration, attachment, proliferation and differentiation. Acta Biomaterialia, epublished. doi:10.1016/j.actbio.2009.04.022   
  • Yamada M, Ogawa T. Chemodynamics underlying N-acetyl cysteine-mediated bone cement monomer detoxification. Acta Biomaterialia, in press
  • Suzuki T, Hori N, Att W, Iwasa F, Ueno T, Kubo K, Maeda H. Ogawa T. UV Treatment overcomes Time-Related Degrading Bioactivity of Titanium. Tissue Engineering, epublished, doi:10.1089/ten.TEA.2008.0568.
  • Att W, Hori N, Iwasa F, Yamada M, Ueno T, Ogawa T. The effect of UV-photofunctionalization on the time-related bioactivity of titanium and chromium-cobalt alloys. Biomaterials, in press
  • Sato N, Kubo K, Yamada M, Hori N, Suzuki T, Maeda H, Ogawa T. Osteoblast mechanoresponse on Ti with different surface topographies. J Dent Res, in press

  
         
   


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